Modelling cognitive deficits in Parkinson's disease: Is CA2 a gateway for hippocampal synucleinopathy?


Cinar E. , Yalcin-Cakmakli G. , Saka E., Ulusoy A., Yuruker S., ELİBOL B. , ...Daha Fazla

EXPERIMENTAL NEUROLOGY, cilt.330, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Background: Cognitive dysfunction is one of the most disabling non-motor symptoms of Parkinson's disease (PD), though its pathological correlates still remain elusive. Hippocampal Lewy pathology has recently been correlated by compelling evidence from post-mortem and imaging studies. Animal models recapitulating cognitive impairment in PD are essential to better understand the underlying pathophysiology. To investigate the hippocampal involvement in cognitive dysfunction of PD, we generated an experimental model by inducing midbrain and hippocampal alpha-synuclein pathology simultaneously.