Preparation and evaluation of bismuth sulfide and magnetite-based theranostic nanohybrid as drug carrier and dual MRI/CT contrast agent


Nosrati H., Salehiabar M., Mozafari F., Charmi J., ERDOĞAN N., Ghaffarlou M., ...More

APPLIED ORGANOMETALLIC CHEMISTRY, vol.36, no.11, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 11
  • Publication Date: 2022
  • Doi Number: 10.1002/aoc.6861
  • Journal Name: APPLIED ORGANOMETALLIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, BIOSIS, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, Metadex, DIALNET, Civil Engineering Abstracts
  • Keywords: bismuth, contrast agent, CT, iron oxide, MRI, IRON-OXIDE NANOPARTICLES, FACILE SYNTHESIS, RESONANCE, TOXICITY, PH, THERAPY
  • Hacettepe University Affiliated: Yes

Abstract

Due to the increased incidence and population growth that has been leading to growing number of cases worldwide, early diagnosis and treatment of cancer is crucial. Low density cancer tissue cannot be diagnosed before progressing toward a metastatic stage. Thus, theranostic systems play a significant role in assisting timely diagnosis and treatment. The combination of magnetic resonance imaging (MRI) and computed tomography (CT) contrast agents in a single probe is of high importance and necessity, where individual strengths of each approach can be merged while shortcomings of each modality could be compensated. With this motivation, we have developed and synthesized Bi2S3@BSA-Fe3O4 nanoparticles as a dual MRI/CT contrast agent and carrier of curcumin (CUR) as natural anticancer drug. The nanoparticles shortened both the longitudinal (T-1) and transverse (T-2), MRI relaxation times, with a more distinct effect on producing negative contrast (T-2) images with a relaxivity (r(2)) of 54.73 mM(-1) s(-1). The magnetite/bismuth hybrid nanoparticle also was capable of increasing CT image contrast. Further, in vitro cytotoxicity assay showed high biocompatibility of the synthesized nanoparticles. Furthermore, in vitro cytotoxicity assay on cancer cells showed high anticancer activity of the synthesized nanoparticles.