CLINICAL BREAST CANCER, vol.17, no.2, pp.91-99, 2017 (SCI-Expanded)
This randomized phase II trial compared first-line all-oral vinorelbine/capecitabine, gemcitabine/paclitaxel, and gemcitabine/docetaxel for HER2-negative metastatic breast cancer. Disease control rates (primary end point) were 73%, 78%, and 80%, respectively; median progression-free survival was 7.6, 9.0, and 11.4 months; median overall survival was 30 to 31 months with all regimens. All-oral vinorelbine/capecitabine is an active first-line regimen, and avoids alopecia and frequent intravenous administrations.