Research Information System
in: Fundamentals and Therapeutic Applications of Liposomes, Prashant Kesharwani, Editor, Academic Press , London, pp.475-504, 2026
Parkinson's disease (PD), the most common neurodegenerative disease after Alzheimer's disease, is characterized by motor symptoms such as rigidity, bradykinesia, resting tremor, and postural instability. Clinical diagnosis based on motor symptoms is generally not useful for early diagnosis. Although functional imaging modalities such as magnetic resonance imaging (MRI), positron emission tomography (PET), and single photon emission computed tomography (SPECT) provide important benefits in early and differential diagnosis, there is still no ideal method for diagnosis. Although many advances have been made in the treatment of PD, current treatment options are aimed at alleviating motor and non-motor symptoms. The blood–brain barrier poses the biggest problem in both transporting diagnostic and therapeutic agents to the brain. Liposomes are promising delivery systems to overcome this problem.