Biodistribution and computed tomography studies on iopromide liposomes


Erdogan S. , Ozer A. Y. , Ercan M., Aydin K., Hincal A.

STP PHARMA SCIENCES, cilt.8, ss.133-137, 1998 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 8 Konu: 2
  • Basım Tarihi: 1998
  • Dergi Adı: STP PHARMA SCIENCES
  • Sayfa Sayıları: ss.133-137

Özet

Liposomes containing iopromide were prepared by film method followed by extrusion. Biodistribution and computed tomography imaging efficiency were evaluated in rats. Liposomes were taken up by the reticulo-endothelial system localized in the macrophages or Kupffer cells. The best biodistribution and computed tomography enhancement of the liver images were obtained with formulation E2 (PL100/SA/Chol 7/2/4 molar ratio, liquid crystalline state).