Biodistribution and computed tomography studies on iopromide liposomes
STP PHARMA SCIENCES, cilt.8, sa.2, ss.133-137, 1998 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 8 Sayı: 2
- Basım Tarihi: 1998
- Dergi Adı: STP PHARMA SCIENCES
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.133-137
- Hacettepe Üniversitesi Adresli: Evet
Özet
Liposomes containing iopromide were prepared by film method followed by extrusion. Biodistribution and computed tomography imaging efficiency were evaluated in rats. Liposomes were taken up by the reticulo-endothelial system localized in the macrophages or Kupffer cells. The best biodistribution and computed tomography enhancement of the liver images were obtained with formulation E2 (PL100/SA/Chol 7/2/4 molar ratio, liquid crystalline state).