Immunohistochemical Analysis of SMARCB1/INI-1 Expression in Collecting Duct Carcinoma

Elwood H., Chaux A., Schultz L., Illei P. B., Baydar D. E., Billis A., ...More

UROLOGY, vol.78, no.2, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 78 Issue: 2
  • Publication Date: 2011
  • Doi Number: 10.1016/j.urology.2011.04.043
  • Journal Name: UROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Hacettepe University Affiliated: No

Abstract

OBJECTIVES Collecting duct carcinoma (CDC) is a rare and aggressive renal tumor with a tendency to involve the renal sinus. CDC displays variable morphologic features that can overlap with those of renal medullary carcinoma. The loss of SMARCB1/INI1 tumor suppressor gene, initially found in pediatric malignant rhabdoid tumors of the central nervous system, kidneys, and soft tissues, was also recently described in renal medullary carcinoma. The current immunohistochemical study assessed SMARCB1/INI1 expression in a series of CDCs.