An efficient water-mediated synthetic route for the alkylation of heteroarenes


SEYİTDANLIOĞLU P. , Hanashalshahaby E. H. A. , ÜNALEROĞLU C.

TURKISH JOURNAL OF CHEMISTRY, cilt.42, ss.1598-1610, 2018 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 42 Konu: 6
  • Basım Tarihi: 2018
  • Doi Numarası: 10.3906/kim-1802-18
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Sayfa Sayıları: ss.1598-1610

Özet

An efficient synthetic route has been described for the alkylation of 1H-indole, 1H-benzimidazole, and 1H-benzotriazole. This approach features the alkylation of heteroaromatics through in situ generated enones from ketonic Mannich bases under metal-free conditions. A series of alkylated heteroaromatics have been synthesized via the K10 catalyzed alkylation reactions of these heteroaromatics with a variety of ketonic Mannich bases. Environmentally benign K10 catalyst, water-mediated mild reaction conditions, and the efficient synthesis of alkylated products are the advantages of this alkylation method.