An efficient water-mediated synthetic route for the alkylation of heteroarenes

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SEYİTDANLIOĞLU P., Hanashalshahaby E. H. A., ÜNALEROĞLU C.

TURKISH JOURNAL OF CHEMISTRY, vol.42, no.6, pp.1598-1610, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 6
  • Publication Date: 2018
  • Doi Number: 10.3906/kim-1802-18
  • Journal Name: TURKISH JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1598-1610
  • Hacettepe University Affiliated: Yes

Abstract

An efficient synthetic route has been described for the alkylation of 1H-indole, 1H-benzimidazole, and 1H-benzotriazole. This approach features the alkylation of heteroaromatics through in situ generated enones from ketonic Mannich bases under metal-free conditions. A series of alkylated heteroaromatics have been synthesized via the K10 catalyzed alkylation reactions of these heteroaromatics with a variety of ketonic Mannich bases. Environmentally benign K10 catalyst, water-mediated mild reaction conditions, and the efficient synthesis of alkylated products are the advantages of this alkylation method.