Twelve new 2,6,6-trimethyl-3-carbomethoxy(ethoxy) 4-aryl-1,4,5,6,7,8-hexahydroquinoline derivatives have been prepared. Their structures were confirmed by IR, H-1 NMR, mass and elemental analysis. The calcium antagonistic activity of these compounds was tested in rat aortic rings precontracted with 30 mM K+. The compounds IVa, IVc, IVe, IVf, IVh-I induced concentration dependent relaxation response in precontracted aortic rings. The concentrations that cause 50% relaxation of K+-contraction were also calculated for the compounds IVe, IVf, IVj. According to pharmacological results, compound IVI exert the most activity and compound IVc has been found to be least active in this series. The methyl ester derivatives carrying mono halogensubstitutent in the phenyl ring, the activity order is F > Br > Cl. Replacement of the substituted phenyl ring with the pyridine ring increases the activity. (C) 2000 Elsevier Science S.A. All rights reserved.