Dynamics in children and adolescents who experience varicella zoster virus infections after haematopoietic stem cell transplantation: A case-control study


AYTAÇ S. A. , YALÇIN S. S. , Kucukbayrak O., ÇETİN M., Uckan D.

Epidemiology and Infection, vol.139, no.11, pp.1701-1709, 2011 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 139 Issue: 11
  • Publication Date: 2011
  • Doi Number: 10.1017/s0950268810003031
  • Journal Name: Epidemiology and Infection
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1701-1709

Abstract

We evaluated the incidence of varicella-zoster virus (VZV) infections, including herpes zoster (HZ), and investigated the associated risk factors for HZ and compared lymphocyte subsets of these patients at 1, 3 and 6 months following haematopoietic stem cell transplantation (HSCT) in a case-control study in children and adolescents. The incidence of HZ infection at the first year after HSCT was 17/125 (13·6%). The cumulative incidence of HZ infection was 22/125 (17·6%). Sixteen (73%) cases with HZ and 11 (32%) cases in the control group had a diagnosis of malignant disorder. No significant difference was noted between the HZ group and the control group in absolute lymphocyte number and subsets (except WBC) at the pre-transplant evaluation. Pre-transplant WBC count was statistically lower in the HZ group (P<0·05). The CD4/CD8 ratios were lower in the HZ group during the first 6 months after HSCT, and the decrease was statistically significant at 6 months compared to the control group. In conclusion, patients undergoing HSCT for a malignant disorder had a significantly higher risk of VZV infection than those with non-malignant disorders and pretransplant donor characteristics were not helpful in predicting risk of post-transplant VZV infection. © Copyright Cambridge University Press 2011.