Chemotherapy and biological treatment options in breast cancer patients with brain metastasis: an update

Arslan C., Dizdar O., ALTUNDAG K.

EXPERT OPINION ON PHARMACOTHERAPY, vol.15, no.12, pp.1643-1658, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 15 Issue: 12
  • Publication Date: 2014
  • Doi Number: 10.1517/14656566.2014.929664
  • Journal Name: EXPERT OPINION ON PHARMACOTHERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1643-1658
  • Hacettepe University Affiliated: Yes

Abstract

Introduction: Breast cancer (BC) is the second most common cause of CNS metastasis. Ten to 20% of all, and 38% of human epidermal growth factor-2 (+), metastatic BC patients experience brain metastasis (BM). Prolonged survival with better control of systemic disease and limited penetration of drugs to CNS increased the probability of CNS metastasis as a sanctuary site of relapse. Treatment of CNS disease has become an important component of overall disease control and quality of life.