Chemotherapy and biological treatment options in breast cancer patients with brain metastasis: an update
EXPERT OPINION ON PHARMACOTHERAPY, vol.15, no.12, pp.1643-1658, 2014 (SCI-Expanded, Scopus)
- Publication Type: Article / Review
- Volume: 15 Issue: 12
- Publication Date: 2014
- Doi Number: 10.1517/14656566.2014.929664
- Journal Name: EXPERT OPINION ON PHARMACOTHERAPY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.1643-1658
- Hacettepe University Affiliated: Yes
Abstract
Introduction: Breast cancer (BC) is the second most common cause of CNS metastasis. Ten to 20% of all, and 38% of human epidermal growth factor-2 (+), metastatic BC patients experience brain metastasis (BM). Prolonged survival with better control of systemic disease and limited penetration of drugs to CNS increased the probability of CNS metastasis as a sanctuary site of relapse. Treatment of CNS disease has become an important component of overall disease control and quality of life.