Local granulocyte-macrophage colony-stimulating factor improves incisional wound healing in adriamycin-treated rats

Gulcelik M., Dinc S., Dinc M., Yenidogan E., Ustun H., Renda N., ...Daha Fazla

SURGERY TODAY, cilt.36, sa.1, ss.47-51, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 1
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1007/s00595-005-3097-1
  • Dergi Adı: SURGERY TODAY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.47-51
  • Hacettepe Üniversitesi Adresli: Hayır

Özet

Purpose. Neoadjuvant treatment is often given for locally advanced malignancies; however, clinical and experimental studies have shown that some chemotherapeutic agents impair wound healing. It has been reported that granulocyte-macrophage colony-stimulating factor (GM-CSF) applied locally improves dermal wound healing. Thus, we investigated the effects of locally injected GM-CSF on abdominal wounds impaired by adriamycin, a widely used chemotherapeutic agent.