Local granulocyte-macrophage colony-stimulating factor improves incisional wound healing in adriamycin-treated rats

Gulcelik M., Dinc S., Dinc M., Yenidogan E., Ustun H., Renda N., ...More

SURGERY TODAY, vol.36, no.1, pp.47-51, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 1
  • Publication Date: 2006
  • Doi Number: 10.1007/s00595-005-3097-1
  • Journal Name: SURGERY TODAY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.47-51
  • Hacettepe University Affiliated: No

Abstract

Purpose. Neoadjuvant treatment is often given for locally advanced malignancies; however, clinical and experimental studies have shown that some chemotherapeutic agents impair wound healing. It has been reported that granulocyte-macrophage colony-stimulating factor (GM-CSF) applied locally improves dermal wound healing. Thus, we investigated the effects of locally injected GM-CSF on abdominal wounds impaired by adriamycin, a widely used chemotherapeutic agent.