Will a second biopsy sample affect treatment decisions in patients with chronic hepatitis B?

Ekiz F., YÜKSEL İ., Arikok A. T. , Yilmaz B., Altinbas A., Aktas B., ...More

HEPATOLOGY INTERNATIONAL, vol.10, no.4, pp.602-605, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.1007/s12072-015-9666-5
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.602-605
  • Hacettepe University Affiliated: Yes


Liver biopsy is the gold standard for assessment of fibrosis in patients with hepatitis B. However, it has some disadvantages, including inter-observer and intra-observer variability in biopsy interpretation and specimen variation. A standard biopsy specimen represents only about 0.0002 % of the whole liver. It has been shown that two biopsy samples collected during a procedure have significant influence on the diagnostic performance of interpretation in patients with hepatitis C or non-alcoholic steatohepatitis. Therefore, we aimed to assess the influence of collecting two liver biopsy samples during a single procedure for staging and grading chronic hepatitis B.