Will a second biopsy sample affect treatment decisions in patients with chronic hepatitis B?

Ekiz F., YÜKSEL İ., Arikok A. T., Yilmaz B., Altinbas A., Aktas B., ...More

HEPATOLOGY INTERNATIONAL, vol.10, no.4, pp.602-605, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.1007/s12072-015-9666-5
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.602-605
  • Hacettepe University Affiliated: Yes


Liver biopsy is the gold standard for assessment of fibrosis in patients with hepatitis B. However, it has some disadvantages, including inter-observer and intra-observer variability in biopsy interpretation and specimen variation. A standard biopsy specimen represents only about 0.0002 % of the whole liver. It has been shown that two biopsy samples collected during a procedure have significant influence on the diagnostic performance of interpretation in patients with hepatitis C or non-alcoholic steatohepatitis. Therefore, we aimed to assess the influence of collecting two liver biopsy samples during a single procedure for staging and grading chronic hepatitis B.