Will a second biopsy sample affect treatment decisions in patients with chronic hepatitis B?

Ekiz F., YÜKSEL İ., Arikok A. T. , Yilmaz B., Altinbas A., Aktas B., ...Daha Fazla

HEPATOLOGY INTERNATIONAL, cilt.10, ss.602-605, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 10 Konu: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s12072-015-9666-5
  • Sayfa Sayıları: ss.602-605


Liver biopsy is the gold standard for assessment of fibrosis in patients with hepatitis B. However, it has some disadvantages, including inter-observer and intra-observer variability in biopsy interpretation and specimen variation. A standard biopsy specimen represents only about 0.0002 % of the whole liver. It has been shown that two biopsy samples collected during a procedure have significant influence on the diagnostic performance of interpretation in patients with hepatitis C or non-alcoholic steatohepatitis. Therefore, we aimed to assess the influence of collecting two liver biopsy samples during a single procedure for staging and grading chronic hepatitis B.