Alterations in striatal neuropeptide mRNA produced by repeated administration of L-dopa, ropinirole or bromocriptine correlate with dyskinesia induction in MPTP-treated common marmosets


Tel B. C., Zeng B., Cannizzaro C., Pearce R., Rose S., Jenner P.

NEUROSCIENCE, vol.115, no.4, pp.1047-1058, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 115 Issue: 4
  • Publication Date: 2002
  • Doi Number: 10.1016/s0306-4522(02)00535-3
  • Journal Name: NEUROSCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1047-1058
  • Hacettepe University Affiliated: Yes

Abstract

Chronic administration of L-DOPA to MPTP-treated common marmosets induces marked dyskinesia while repeated administration of equivalent antiparkisonian doses of ropinirole and bromocriptine produces only mild involuntary movements. The occurrence of dyskinesia has been associated with an altered balance between the direct and indirect striatal output pathways. Using in situ hybridisation histochemistry, we now compare the effects of these drug treatments on striatal preproenkephalin-A (PPE-A) and adenosine A(2a) receptor mRNA expression as markers of the indirect pathway and striatal preprotachykinin (PPT) mRNA and preproenkephalin-B (PPE-B, prodynorphin) mRNA expression as markers of the direct pathway.