Alterations in striatal neuropeptide mRNA produced by repeated administration of L-dopa, ropinirole or bromocriptine correlate with dyskinesia induction in MPTP-treated common marmosets

Tel B. C., Zeng B., Cannizzaro C., Pearce R., Rose S., Jenner P.

NEUROSCIENCE, cilt.115, sa.4, ss.1047-1058, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 115 Sayı: 4
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1016/s0306-4522(02)00535-3
  • Dergi Adı: NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1047-1058
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Chronic administration of L-DOPA to MPTP-treated common marmosets induces marked dyskinesia while repeated administration of equivalent antiparkisonian doses of ropinirole and bromocriptine produces only mild involuntary movements. The occurrence of dyskinesia has been associated with an altered balance between the direct and indirect striatal output pathways. Using in situ hybridisation histochemistry, we now compare the effects of these drug treatments on striatal preproenkephalin-A (PPE-A) and adenosine A(2a) receptor mRNA expression as markers of the indirect pathway and striatal preprotachykinin (PPT) mRNA and preproenkephalin-B (PPE-B, prodynorphin) mRNA expression as markers of the direct pathway.