Amplification of the c-myc oncogene in non-small cell lung cancer

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Ozkara H. A., OZKARA S., TOPCU S., CRISS W.

TUMORI J, cilt.85, sa.6, ss.508-511, 1999 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 85 Sayı: 6
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1097/coc.0000000000000012
  • Dergi Adı: TUMORI J
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.508-511
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Fresh non-small cell lung carcinoma surgical specimens were taken from 17 patients and 3 controls and screened for genetic abnormalities of the c-myc oncogene, Southern blot hybridization analysis demonstrated two- to fivefold amplification of the c-myc gene in 10 cases, i.e., 7 of 13 epidermoid lung carcinomas, 2 of 3 adenocarcinomas and 1 of 1 osteogenic sarcoma metastatic to the lung. Two- to fivefold amplification was observed in tissues from stage III and IV epidermoid carcinomas and adenocarcinomas of the lung. A correlation between cancer stage and c-myc gene amplification was found.