Aim of the study: The seeds of nigella (black cumin) (Nigella sativa L.) have been widely used as a natural remedy, either alone or in combination with bee products, for the treatment of many acute as well as chronic conditions for centuries. especially in the Middle East and Southeast Asia. In consideration of potential utilization, in recent years the seeds have been extensively studied in terms of pharmacological effects. It has been shown that the seeds have significant effects on multiple biological systems. In addition, the protective roles of the seeds with bee products (honey and wax) have been recently proved.