Effects of pegylated interferon α on fibrinolytic parameters in patients with chronic hepatitis C


Gokmen A., Ustundag Y., Oztoprak N., Aydemir S., Tekin I. O. , Cakal B., ...Daha Fazla

Clinical and Applied Thrombosis/Hemostasis, cilt.17, ss.449-453, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 17 Konu: 5
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1177/1076029610371475
  • Dergi Adı: Clinical and Applied Thrombosis/Hemostasis
  • Sayfa Sayıları: ss.449-453

Özet

Interferon (IFN) interacts with endothelial cells and modulates the functions of these cells. In our study, we aimed to determine the effects of treatment with pegylated IFN-alpha (peg-IFN-alpha) on fibrinolytic parameters in patients with chronic hepatitis C. Fifteen patients with chronic hepatitis C were treated with peg-IFN-a once per week plus daily oral ribavirin. Euglobulin lysis time (ELT), plasma levels of D-dimer, tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor 1 (PAI-1), and thrombin activatable fibrinolysis inhibitor (TAFI) were determined before treatment, 2 weeks, 1 month, and 3 months after the initiation of the treatment. Plasma levels of t-PA increased significantly 1 month and 3 months after the treatment (P < .05). The PAI-1 and TAFI levels in 2 weeks, 1 month and 3 months after treatment were not statistically different as compared with pretreatment levels (P > .05) No significant difference in plasma D-dimer levels was observed during peg-IFN-alpha treatment (P > .05). There was a significant decrease in ELT 1 month and 3 months after the treatment (P < .05). Our results indicated that treatment with peg-IFN-alpha may be associated with enhanced fibrinolysis,