Crypthophilic acids A, B, and C: Resin glycosides from aerial parts of Scrophularia crypthophila

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Calis I., Sezgin Y., Donmez A. A., Rueedi P., Tasdemir D.

JOURNAL OF NATURAL PRODUCTS, vol.70, no.1, pp.43-47, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 70 Issue: 1
  • Publication Date: 2007
  • Doi Number: 10.1021/np060511k
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.43-47
  • Hacettepe University Affiliated: Yes


The water-soluble part of the methanolic extract from the aerial parts of Scrophularia crypthophila, through chromatographic methods, yielded three new resin glycosides, crypthophilic acids A-C (1-3). Compounds 1-3 are tetraglycosides of (+)-3S,12S-dihydroxypalmitic acid. The structures of these and 10 known compounds were elucidated by spectroscopic and chemical means. All natural resin glycosides known so far have been obtained from Convolvulaceae plants; this is the first report of such glycosides from another, taxonomically unrelated family (Scrophulariaceae).