Akademik Veri Yönetim Sistemi
Hacettepe University Journal of the Faculty of Pharmacy, cilt.43, sa.1, ss.78-98, 2023 (Scopus)
The in vitro release tests which examine the release properties of the drug from the dosage form provide the opportunity to investigate the in vitro availability of the drug product as well as to compare its equivalency to other products. In order to obtain accurate and reliable results from in vitro release tests, it is crucial to select the right release test method and suitable release conditions (such as temperature, release medium, pH, agitation/flow rate, etc.). Although there are compendial in vitro release test methods available for various dosage forms, up to date there are no tests described for nanoparticulate systems in any pharma-copeia. In this review, the methods (such as sampling and separation, membrane diffusion, continuous flow, etc.) applied to test the in vitro drug release from nanoparticulate systems will be reviewed. The recent applications of these methods in different particulate systems will be summarized and the advantages and limitations of these test methods will be discussed.