The association between platelet-to-lymphocyte ratio and inflammatory markers with the severity of aortic stenosis
BIOMARKERS IN MEDICINE, cilt.10, sa.4, ss.367-373, 2016 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 10 Sayı: 4
- Basım Tarihi: 2016
- Doi Numarası: 10.2217/bmm-2015-0016
- Dergi Adı: BIOMARKERS IN MEDICINE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.367-373
- Anahtar Kelimeler: aortic stenosis, inflammation, platelet-to-lymphocyte ratio, VALVE STENOSIS, PLATELET/LYMPHOCYTE RATIO, MYOCARDIAL-INFARCTION, EARLY LESION, DISEASE, PATHOGENESIS, NEUTROPHIL, MORTALITY, SCLEROSIS, RISK
- Hacettepe Üniversitesi Adresli: Evet
Özet
Aim: Platelet-to-lymphocyte ratio (PLR) was proposed as a novel indirect marker of inflammation. We aimed to evaluate the relationship between PLR and aortic stenosis (AS). Patients & methods: The study population included 453 patients of which 98 patients with severe AS, 206 patients with mild-to-moderate AS and 149 patients as control. Results: PLR was significantly increased in parallel to the severity of AS (p < 0.001). There was significant positive correlation between PLR and maximum, and mean systolic transaortic gradient (all p < 0.001). Also, PLR was correlated with C-reactive protein and neutrophil-to-lymphocyte ratio (all p < 0.001) and PLR was independently associated with the presence of AS (p < 0.001). Conclusion: We found a significant relationship between PLR and AS.