Effects of octreotide and a-tocopherol on bacterial translocation in experimental intestinal obstruction: A microbiological, light and electronmicroscopical study

Reis E., Kama N., Coskun T., Korkusuz P., Ors U., Aksoy M., ...More

HEPATO-GASTROENTEROLOGY, vol.44, no.15, pp.656-663, 1997 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 15
  • Publication Date: 1997
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.656-663
  • Hacettepe University Affiliated: Yes


Background/Aims: Bacterial translocation induced by intestinal obstruction is suggested to be due to increased intestinal luminal volume, leading to intestinal overgrowth with certain enteric microorganisms and intestinal mucosal damage. If this suggestion is true, maintenance of intestinal mucosal integrity by a cytoprotective agent, alpha-tocopherol, and inhibition of gastrointestinal secretions by octreotide should decrease the incidence of bacterial translocation and extent of mucosal injury due to intestinal obstruction.