The analysis of interleukin-1 receptor antagonist and interleukin-1beta gene polymorphisms in Turkish FMF patients: do they predispose to secondary amyloidosis?

Balci-Peynircioğlu B., Taşkiran Z. E., Türel B., Arici M., Bakkaloğlu A., Ozen S., ...More

Clinical and experimental rheumatology, vol.26, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26
  • Publication Date: 2008
  • Journal Name: Clinical and experimental rheumatology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Hacettepe University Affiliated: Yes

Abstract

Objective. Amyloid development in familial Mediterranean fever (FMF) patients is associated with acute phase response and the acute phase reactant serum amyloid A which is induced by IL-1 beta. Its concentration can increase to more than 1000 fold during inflammation. In view of the inflammatory nature of FMF disease we have investigated whether IL-1 beta and IL-1 receptor antagonist gene polymorphisms may be involved in amyloid development in FMF patients.