Clonal B-cell proliferations developing in the background of primary cutaneous CD4(+) small/medium T-cell lymphoproliferative disorder: A case series
JOURNAL OF CUTANEOUS PATHOLOGY, cilt.49, sa.11, ss.971-977, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 49 Sayı: 11
- Basım Tarihi: 2022
- Doi Numarası: 10.1111/cup.14296
- Dergi Adı: JOURNAL OF CUTANEOUS PATHOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.971-977
- Anahtar Kelimeler: B-cell clonal population, EBV positivity, primary cutaneous CD4(+) small, medium lymphoproliferative disorder, LYMPHOMA
- Hacettepe Üniversitesi Adresli: Evet
Özet
Clonal B-cell proliferations and B-cell lymphomas may co-occur in the background of follicular helper T-cell (TFH)-derived lymphomas, most associated with EBV, which has been a well-known fact for many years in the prototypical entity "TFH lymphoma, angioimmunoblastic-type." Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder (CD4(+) PCSM-LPD) is also a TFH-derived clonal proliferation. We searched the archives and identified four cases of CD4(+) PCSM-LPD with accompanying clonal B-cell proliferation (one of which showed EBER positivity), and one longstanding case of CD4(+) PCSM-LPD, in the background of which a B-cell lymphoma had developed. These five cases broaden experience on CD4(+) PCSM-LPD with accompanying B-cell proliferations and also support routine evaluation of these cases with EBV in situ hybridization, to better determine whether or not there is an association with EBV.