CD-34 selected hematopoetic stem cell transplantation from HLA identical family members for fanconi anemia


Balci Y. I. , Akdemir Y., GÜMRÜK F. , ÇETİN M. , Arpaci F., Uckan D.

PEDIATRIC BLOOD & CANCER, cilt.50, ss.1065-1067, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 50 Konu: 5
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1002/pbc.21424
  • Dergi Adı: PEDIATRIC BLOOD & CANCER
  • Sayfa Sayıları: ss.1065-1067

Özet

Hematopoetic stem cell transplantation, even from an HLA 6/6 identical family member is associated with an increased frequency of complication in fanconi anemia (FA). The increased susceptibility for chromosomal breaks has been suggested as a contributory factor for increased risk of toxicity, graft versus host disease (GVHD) and increased incidence of post-transplant solid tumors. Therefore, non-irradiation based preparative regimens usually containing fludarabine and T-cell depletion of HLA genoidentical bone marrow cells have increasingly been used in patients with FA. Here, we report three children with FA who underwent CD-34 selected HSCT from HLA-identical family donors with reduced intensity fludarabine-based regimen.