Resveratrol Shows Vasoprotective Effect Reducing Oxidative Stress Without Affecting Metabolic Disturbances in Insulin-dependent Diabetes of Rabbits


Akar F. , Pektas M. B. , Tufan C., Soylemez S., Sepici A., ULUS A. T. , ...Daha Fazla

CARDIOVASCULAR DRUGS AND THERAPY, cilt.25, ss.119-131, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 25 Konu: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1007/s10557-010-6255-7
  • Dergi Adı: CARDIOVASCULAR DRUGS AND THERAPY
  • Sayfa Sayıları: ss.119-131

Özet

Resveratrol has been shown to have vasoprotective effects by upregulating oxidative defense mechanisms in a variety of pathophysiological conditions. However, the effect of resveratrol on diabetic oxidative stress and vascular and metabolic abnormalities is not completely understood. Therefore, this study was designed to evaluate whether long-term resveratrol supplementation has a protective effect on vascular function and integrity in association with metabolic parameters and oxidative stress in insulin-dependent diabetes.