Lack of association between TLR4 polymorphism and severe gram-negative bacterial infection in neonates

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Ozgur T. T., Yel L., YİĞİT Ş., Mesci L., Sanal O., Tezcan I., ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.39, no.3, pp.423-427, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 3
  • Publication Date: 2009
  • Doi Number: 10.3906/sag-0811-20
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.423-427
  • Hacettepe University Affiliated: Yes


Aim: Gram-negative microorganisms are responsible for a significant percentage of systemic bacterial infections in neonates, which tend to progress to sepsis. Toll-like receptor 4 (TLR4), one of the receptors in the innate immune system, binds to the lipopolysaccharide (LPS) present on gram-negative bacteria. Following ligation, a cascade of cellular signals leads to activation of NF kappa B, resulting in the generation Of Such proinflammatory cytokines as TNF alpha, IL-1, IL-2, and IL-6. These are the mediators of inflammation, which is the cellular response to activation of the innate immune system. As such, TLR4 appears to be a very likely candidate involved in the immediate immune response to grain-negative bacteria. Two polymorphisms in the TLR4 gene, Asp299Gly and Thr399Ile, cause a reduction in inflammatory cytokine response to LPS. We sought to determine if there was any correlation between these polymorphisms and severe gram-negative infection in neonates.