Acute Budd-Chiari syndrome associated with activated protein C resistance during intravenous anticoagulant treatment

YILDIZ O. B., Oran B., Buyukasik Y., Haznedaroglu I., Cekirge S., Kirazli S.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, vol.4, no.3, pp.220-223, 1998 (SCI-Expanded) identifier identifier


The Budd-Chiari syndrome is a rare but serious condition defined as hepatic venous outflow obstruction. This article presents a case of acute Budd-Chiari syndrome in a 13-year-old woman with activated protein C resistance while she was bring treated with intravenous heparin infusion for previously documented deep venous thrombosis. Activated protein C resistance caused by factor V Leiden mutation has emerged as the most prevalent hereditary cause of venous thromboembolism and should be considered as an etiologic factor in patients with Budd-Chiari syndrome.