Epigenetic effects of endocrine disrupting chemicals: Bisphenol A Epigenetik etkileri olan endokrin bozucu kimyasal maddeler: Bisfenol A

Erkekoğlu P., Koçer-Gümüşel B.

Hacettepe University Journal of the Faculty of Pharmacy, vol.36, no.2, pp.186-203, 2016 (Scopus) identifier


© 2016, Hacettepe University, Faculty of Pharmacy. All rights reserved.In the last decade, several comprehensive studies showed that epigenetic mechanisms could alter gene expressions and this phenomenon could lead to numerous diseases, particularly to cancer. Data indicate that some environmental contaminants, to which humans are widely exposed to, can cause epigenetic alterations. These alterations can play roles in the pathogenesis of some diseases. Bisphenol A (BPA) is one of the most abundant environmental contaminants and it is a chemical widely used in several fields, specifically in plastic industry. It is known that BPA has epigenetic effects in different periods of life and these effects have wide range of outcomes, like affecting fertility and cancer promotion. In this review, we will mainly focus on epigenetic mechanisms and the results of in vitro and in vivo studies, in which.the epigenetic effects of BPA were evaluated, will be presented.