Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans

Levine S., Nguyen T., Taylor N., Friscia M. E., Budak M. T., Rothenberg P., ...More

NEW ENGLAND JOURNAL OF MEDICINE, vol.358, no.13, pp.1327-1335, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 358 Issue: 13
  • Publication Date: 2008
  • Doi Number: 10.1056/nejmoa070447
  • Journal Name: NEW ENGLAND JOURNAL OF MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1327-1335
  • Hacettepe University Affiliated: No

Abstract

Background: The combination of complete diaphragm inactivity and mechanical ventilation (for more than 18 hours) elicits disuse atrophy of myofibers in animals. We hypothesized that the same may also occur in the human diaphragm.