Scintigraphic imaging of infections with 99m-Tc-labelled glutathione liposomes

Erdogan S., Ozer A., Ercan M., Hincal A.

JOURNAL OF MICROENCAPSULATION, cilt.17, sa.4, ss.459-465, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 4
  • Basım Tarihi: 2000
  • Dergi Adı: JOURNAL OF MICROENCAPSULATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.459-465
  • Anahtar Kelimeler: liposome, HMPAO (hexamethyl propylamine oxime), glutathione, infection imaging, scintigraphy, RATS
  • Hacettepe Üniversitesi Adresli: Evet

Özet

In this study, liposomes containing glutathione were evaluated to detect infection in mice. Glutathione liposomes were labelled by using 99mTc-Iabelled-HMPAO (hexamethyl propylamine oxime). Mice were infected in the thigh by intramuscular injection with turbentine. Labelled liposomes were applied to the tail vein of the mice intravenously. At fixed time intervals they were sacrificed. The animals were imaged under a gamma camera. Then, tissue samples were excised and radioactivity of all organs was counted. Abscess-to-muscle, abscess-to-liver, and abscess-to-spleen ratios were calculated. The ratios of abscess-to-muscle were found to be 1.6 and 11.6 at 1 h and 24 h, respectively. According to these data, the abscess can be defined at Ih and it became more clear with time.