Same same but different: A Web-based deep learning application revealed classifying features for the histopathologic distinction of cortical malformations

Kubach J., Muhlebner-Fahrngruber A., Soylemezoglu F., Miyata H., Niehusmann P., Honavar M., ...Daha Fazla

EPILEPSIA, cilt.61, sa.3, ss.421-432, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 61 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1111/epi.16447
  • Dergi Adı: EPILEPSIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.421-432
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objective The microscopic review of hematoxylin-eosin-stained images of focal cortical dysplasia type IIb and cortical tuber of tuberous sclerosis complex remains challenging. Both entities are distinct subtypes of human malformations of cortical development that share histopathological features consisting of neuronal dyslamination with dysmorphic neurons and balloon cells. We trained a convolutional neural network (CNN) to classify both entities and visualize the results. Additionally, we propose a new Web-based deep learning application as proof of concept of how deep learning could enter the pathologic routine.