Formulation and characterization of formaldehyde cross-linked degradable starch microspheres containing terbutaline sulfate

Selek H., Sahin S., Kas H. S., Hincal A. A., Ponchel G., Ercan M. T., ...Daha Fazla

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, cilt.33, sa.2, ss.147-154, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 2
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1080/03639040600735046
  • Dergi Adı: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.147-154
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Preparation of starch microspheres using epichlorohydrin is a time consuming method and requires around 18 hr for cross-linking reaction. To reduce reaction time, terbutaline sulfate (TBS) loaded degradable starch microspheres (DSM) were prepared using formaldehyde as the cross-linking agent. All microspheres were spherical in shape and had a porous, rough surface with a mean particle size of 18-24 mu m. Whatever the cross-linking time, it was seen that the release of the TBS was not complete during the release experiments. The influence of enzyme on the degradation of microspheres was moderate. Following intravenous administration, initial uptake of microspheres by the lung was higher than those of other organs.