Effect of low-dose N-acetyl-cysteine infusion on tourniquet-induced ischaemia-reperfusion injury in arthroscopic knee surgery

Saricaoglu F., Dal D., Salman A., Atay O., Doral M., Salman M., ...More

ACTA ANAESTHESIOLOGICA SCANDINAVICA, vol.49, no.6, pp.847-851, 2005 (SCI-Expanded) identifier identifier identifier


Background: Temporary occlusion of blood flow is used during arthroscopic knee surgery in order to provide a bloodless surgical field. The resulting ischaemia-reperfusion causes lipid peroxidation, which contributes to tissue injury. The aim of the study was to investigate the effect of low-dose n-acetyl cysteine (NAC) infusion on oxidative stress by determining malondialdehyde (MDA) levels during arthroscopic knee surgery.