Effect of low-dose N-acetyl-cysteine infusion on tourniquet-induced ischaemia-reperfusion injury in arthroscopic knee surgery

Saricaoglu, F; Dal, D; Salman, AE; Atay, ÖZGÜR; Doral, MAHMUT; Salman, MA; Kilinc, K; Aypar, U

doi:10.1111/j.1399-6576.2005.00722.x

Effect of low-dose N-acetyl-cysteine infusion on tourniquet-induced ischaemia-reperfusion injury in arthroscopic knee surgery

Saricaoglu F., Dal D., Salman A., Atay O., Doral M., Salman M., ...More

ACTA ANAESTHESIOLOGICA SCANDINAVICA, vol.49, no.6, pp.847-851, 2005 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 49 Issue: 6
Publication Date: 2005
Doi Number: 10.1111/j.1399-6576.2005.00722.x
Journal Name: ACTA ANAESTHESIOLOGICA SCANDINAVICA
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.847-851
Hacettepe University Affiliated: Yes

Abstract

Background: Temporary occlusion of blood flow is used during arthroscopic knee surgery in order to provide a bloodless surgical field. The resulting ischaemia-reperfusion causes lipid peroxidation, which contributes to tissue injury. The aim of the study was to investigate the effect of low-dose n-acetyl cysteine (NAC) infusion on oxidative stress by determining malondialdehyde (MDA) levels during arthroscopic knee surgery.