Effect of low-dose N-acetyl-cysteine infusion on tourniquet-induced ischaemia-reperfusion injury in arthroscopic knee surgery


Saricaoglu F., Dal D., Salman A., Atay O. , Doral M. , Salman M., ...More

ACTA ANAESTHESIOLOGICA SCANDINAVICA, vol.49, no.6, pp.847-851, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 6
  • Publication Date: 2005
  • Doi Number: 10.1111/j.1399-6576.2005.00722.x
  • Title of Journal : ACTA ANAESTHESIOLOGICA SCANDINAVICA
  • Page Numbers: pp.847-851

Abstract

Background: Temporary occlusion of blood flow is used during arthroscopic knee surgery in order to provide a bloodless surgical field. The resulting ischaemia-reperfusion causes lipid peroxidation, which contributes to tissue injury. The aim of the study was to investigate the effect of low-dose n-acetyl cysteine (NAC) infusion on oxidative stress by determining malondialdehyde (MDA) levels during arthroscopic knee surgery.