The Effect of Nitrogen Mustard on the Rat Brain and the Therapeutic Value of Proanthocyanidin

Tekiner A., Yucel O., Sargin A. K., Genc O., Can B., Karayilanoglu T., ...More

TURKISH NEUROSURGERY, vol.19, no.4, pp.360-366, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 4
  • Publication Date: 2009
  • Journal Name: TURKISH NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.360-366
  • Hacettepe University Affiliated: Yes

Abstract

AIM: Nitrogen Mustard (NM) is an alkylating agent that damages cellular nuclear DNA after penetrating tissue. This results in cytostatic, mutagenic and cytotoxic effects. We used the electron microscope to investigate the effect of NM gas administered through the dermal and respiratory routes to rats on the brain cortex and also tried to show whether the antioxidant Proanthocyanidin (PC) could decrease this effect.