The Effect of Nitrogen Mustard on the Rat Brain and the Therapeutic Value of Proanthocyanidin


Tekiner A., Yucel O., Sargin A. K. , Genc O., Can B., Karayilanoglu T., ...Daha Fazla

TURKISH NEUROSURGERY, cilt.19, ss.360-366, 2009 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 19 Konu: 4
  • Basım Tarihi: 2009
  • Dergi Adı: TURKISH NEUROSURGERY
  • Sayfa Sayıları: ss.360-366

Özet

AIM: Nitrogen Mustard (NM) is an alkylating agent that damages cellular nuclear DNA after penetrating tissue. This results in cytostatic, mutagenic and cytotoxic effects. We used the electron microscope to investigate the effect of NM gas administered through the dermal and respiratory routes to rats on the brain cortex and also tried to show whether the antioxidant Proanthocyanidin (PC) could decrease this effect.