Comparative proteomics to investigate the in vitro antiproliferative effect of dietary polyphenols against K562 leukemia cells


Celebier M., Simo C., ALTINÖZ S. , Cifuentes A.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.40, ss.95-104, 2015 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 40 Konu: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5505/tjb.2015.29484
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Sayfa Sayıları: ss.95-104

Özet

Objective: The lack of success with classical targeted therapies in cancer treatment has forced researchers to employ either combined therapies or agents that interfere with multiple pathways. In this study, a proteomic evaluation was performed to understand the in vitro antiproliferative effect of dietary compounds against leukemia cells in proteome level. Typical human cell models of leukemia (i.e., wild K562 cells and multi-drug resistant leukemia cells K562/R) were treated with rosemary (Rosmarinus officinalis L.) extracts rich in polyphenols and a comparative proteomic study was performed to identify up-or down-regulated proteins by in vitro antiproliferative effect of polyphenols.