Effect of folic acid supplementation on aluminum accumulation in rats

Baydar T., Nagymajtenyi L., Isimer A., Sahin G.

NUTRITION, cilt.21, sa.3, ss.406-410, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 3
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.nut.2004.07.008
  • Dergi Adı: NUTRITION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.406-410
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objective: Exposure to many xenobiotics may cause depletion of folic acid (folate), which is an essential vitamin for humans. Replacement of folate can be effective in protection against some diseases and in partial or total prevention of adverse effects related to xenobiotics. Aluminum (Al) is the most widely distributed metal in the outer crust of the earth. Its toxicity in humans is well known. However, there is no evidence that folate can decrease accumulation of Al to which humans can be exposed in many ways. The aim of the present study was to quantify, organ Al accumulation and to evaluate whether there is any protective (or reductive) effect of folic acid on Al accumulation.