Successful Treatment of Severe Myasthenia Gravis Developed After Allogeneic Hematopoietic Stem Cell Transplantation With Plasma Exchange and Rituximab


ÜNAL Ş. , SAĞ E. , KUSKONMAZ B. B. , Kesici S. , BAYRAKCİ B. , AYVAZ D. N. , ...Daha Fazla

PEDIATRIC BLOOD & CANCER, cilt.61, ss.928-930, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 61 Konu: 5
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1002/pbc.24799
  • Dergi Adı: PEDIATRIC BLOOD & CANCER
  • Sayfa Sayıları: ss.928-930

Özet

Myasthenia gravis is among the rare complications after allogeneic hematopoietic stem cell transplantation and is usually associated with chronic GVHD. Herein, we report a 2-year and 10 months of age female with Griscelli syndrome, who developed severe myasthenia gravis at post-transplant +22nd month and required respiratory support with mechanical ventilation. She was unresponsive to cyclosporine A, methylprednisolone, intravenous immunoglobulin, and mycophenolate mofetil and the symptoms could only be controlled after plasma exchange and subsequent use of rituximab, in addition to cyclosporine A and mycophenolate mofetil maintenance. She is currently asymptomatic on the 6th month of follow-up. Pediatr Blood Cancer 2014;61:928-930. (c) 2013 Wiley Periodicals, Inc.