Combining transcranial magnetic stimulation and cognitive-behavioral therapy in treatment resistant obsessive-compulsive disorder

TAN O., Hizli Sayar G., ÜNSALVER B. Ö. , ARAT M. M. , Karamustafalioglu O.

ANADOLU PSIKIYATRI DERGISI-ANATOLIAN JOURNAL OF PSYCHIATRY, cilt.16, ss.180-188, 2015 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 16 Konu: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5455/apd.160156
  • Sayfa Sayıları: ss.180-188


Objective: A non-negligible percentage of patients with obsessive-compulsive disorder (OCD) do not respond satisfactorily to treatments. Inpatient cognitive-behavioral therapy (CBT) has provided some relief in even refractory and chronic patients. Repetitive transcranial magnetic stimulation (rTMS) has also provided promising results. However, no studies have combined these two strategies. Methods: Eighteen patients with treatment resistant and chronic OCD who had been hospitalized in order to receive pharmacotherapy, inpatient CBT and rTMS were evaluated on the Yale-Brown Obsession and Compulsion Scale (Y-BOCS) and the Hamilton Depression Rating Scale-17 (HDRS-17). rTMS was applied every day over the left dorsolateral prefrontal cortex for 5 days in a week with parameters of 25 Hz and 1000 pulses. Results: Y-BOCS scores decreased by 59.14%, from 30.72 +/- 6.12 at admission to 12.55 +/- 7.44 when discharged. HDRS-17 scores decreased by 56.80%; from 18.38 +/- 3.94 at admission to 7.94 +/- 5.70 at discharge. The mean numbers of rTMS and CBT sessions were 23.28 +/- 6.78 and 17.17 +/- 5.04 respectively. Discussion: The combination of pharmacotherapy, CBT and rTMS may be effective in treatment resistant and chronic OCD in the short term.