Cytomegalovirus-related congenital nephrotic syndrome with diffuse mesangial sclerosis

Besbas N., Bayrakci U., Kale G., Cengiz A., Akcoren Z., Akinci D., ...More

PEDIATRIC NEPHROLOGY, vol.21, no.5, pp.740-742, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 5
  • Publication Date: 2006
  • Doi Number: 10.1007/s00467-006-0051-4
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.740-742
  • Hacettepe University Affiliated: Yes


This case report describes congenital nephrotic syndrome in a 2-month-old girl associated with cytomegalovirus infection. Histological examination on renal biopsy showed diffuse mesangial sclerosis and cytomegalic inclusion bodies in the tubular cells and in some glomeruli. Cytomegalovirus (CMV) polymerase chain reaction (PCR) titer in serum was high. Remission of pulmonary and renal symptoms was achieved with ganciclovir in 3 weeks. No recurrence of proteinuria was observed during the follow-up period of 14 months. These finding suggested a causal relationship between congenital nephrotic syndrome and cytomegalovirus infection.