Background/aim: COVID-19 syndrome due to the SARS-CoV-2 virus is a currently challenging situation ongoing worldwide. Since the current pandemic of the SARS-CoV-2 virus is a great concern for everybody in the World, the frequently asked question is how and when the COVID-19 process will be concluded. The aim of this paper is to propose hypotheses in order to answer this essential question. As recently demonstrated, SARS-CoV-2 RNAs can be reverse-transcribed and integrated into the human genome. Our main hypothesis is that the ultimate aim of the SARS-CoV-2 virus is the incorporation to human genome and being an element of the intestinal virobiota. Materials and methods: We propose that the SARS-CoV-2 genomic incorporation to be a part of human virobiota is essentially based on three pathobiological phases which are called as the & lsquo;induction & rsquo;, & lsquo;consolidation & rsquo;, and & lsquo;maintenance phases & rsquo;. The phase of & lsquo;recurrence & rsquo; complicates any of these three disease phases based on the viral load, exposure time, and more contagious strains and/or mutants. We have performed the & lsquo;random walk model & rsquo; in order to predict the community transmission kinetics of the virus. Results: Chimerism-mediated immunotherapy at the individual and community level with the help of vaccination seems to be the only option for ending the COVID-19 process. After the integration of SARS-CoV-2 virus into the human genome via the induction, consolidation, and maintenance phases as an element of intestinal virobiota, the chimerism would be concluded. The & lsquo;viral load & rsquo;, the & lsquo;genomic strain of the SARS-CoV-2 & rsquo;, and & lsquo;host immune reaction against the SARS-CoV-2 & rsquo; are the hallmarks of this long journey. Conclusion: Elucidation of the functional viral dynamics will be helpful for disease management at the individual-and community based long-term management strategies.