Mechanism of action of the cisapride-induced vasodilatation in renal vasculature of rat

Tekes E., Bayar B., Emre-Aydingoz S., Tuncer M.

INDIAN JOURNAL OF MEDICAL RESEARCH, vol.119, no.3, pp.115-120, 2004 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 119 Issue: 3
  • Publication Date: 2004
  • Journal Name: INDIAN JOURNAL OF MEDICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.115-120
  • Hacettepe University Affiliated: No

Abstract

Background & objectives: Cisapride is a prokinetic agent with cholinomimetic and 5-HT4 receptor agonistic properties. It has been proposed that cisapride-induced hypotension is partly mediated by cholinergic system. The aim of this study was to investigate the mechanism of cisapride-induced dilatation in the rat isolated perfused kidney.