Camptodactyly, the flexion contracture of the proximal interphalangeal joint usually involves the small finger and may be a component of some autosomal dominant diseases, such as Marfan's syndrome, cranio-carpo-tarsal dystrophy and oculo-dento-digital dysplasia. Camptodactyly may also coexist with anomalies, such as high arched palate, anomalies of scapula, scoliosis, ptosis, hemi-hypertrophy and taurinuria. Hereditary autonomic and sensory neuropathies (HSAN) are a clinically and genetically heterogeneous group of inherited peripheral neuropathies, which primarily affect the peripheral sensory and autonomic nerves. Patients usually have prominent distal sensory loss with complaints of insensitivity to pain. Prominent distal sensory loss may cause chronic ulcerations in the feet and hands, and less frequently, severe complications as extensive soft tissue infections, osteomyelitis and amputations. Herein, we report three sisters with hereditary peripheral polyneuropathy associated with concomitant camptodactyly. Turk J Phys Med Rehab 2012;58:72-4.