B lymphocyte subsets and outcomes in patients with an initial diagnosis of transient hypogammaglobulinemia of infancy

Eroglu, Fehime; Kaya, FATİMA; Cagdas, DENİZ; Ozgur, Tuba; Yılmaz, Togay; Tezcan, Ilhan; Sanal, Ozden

doi:10.1111/sji.12709

B lymphocyte subsets and outcomes in patients with an initial diagnosis of transient hypogammaglobulinemia of infancy

Eroglu F. K., Kaya F. S. F., Cagdas D. N., Ozgur T. T., Yılmaz T., Tezcan I., ...Daha Fazla

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, cilt.88, sa.4, 2018 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 88 Sayı: 4
Basım Tarihi: 2018
Doi Numarası: 10.1111/sji.12709
Dergi Adı: SCANDINAVIAN JOURNAL OF IMMUNOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Anahtar Kelimeler: B lymphocyte subsets, hypogammaglobulinemia, memory B cells, transient hypogammaglobulinemia of infancy, COMMON VARIABLE IMMUNODEFICIENCY, REFERENCE VALUES, CELL SUBPOPULATIONS, CYTOKINE PRODUCTION, CHILDREN, CLASSIFICATION, DEFICIENCIES, BLOOD
Hacettepe Üniversitesi Adresli: Evet

Özet

PurposeTransient hypogammaglobulinemia of infancy (THI) is a common immunodeficiency, but definitive diagnosis can only be made retrospectively. While the pathogenesis is still unknown, abnormalities have been reported in the B cell compartment. In this study, we analysed the B cell subsets of patients with an initial THI diagnosis (n=20) and compared them with those of healthy age-matched Turkish children (n=72).