B lymphocyte subsets and outcomes in patients with an initial diagnosis of transient hypogammaglobulinemia of infancy

Eroglu F. K., Kaya F. S. F., Cagdas D. N., Ozgur T. T., Yılmaz T., Tezcan I., ...More

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, vol.88, no.4, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 88 Issue: 4
  • Publication Date: 2018
  • Doi Number: 10.1111/sji.12709
  • Journal Name: SCANDINAVIAN JOURNAL OF IMMUNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: B lymphocyte subsets, hypogammaglobulinemia, memory B cells, transient hypogammaglobulinemia of infancy, COMMON VARIABLE IMMUNODEFICIENCY, REFERENCE VALUES, CELL SUBPOPULATIONS, CYTOKINE PRODUCTION, CHILDREN, CLASSIFICATION, DEFICIENCIES, BLOOD
  • Hacettepe University Affiliated: Yes

Abstract

PurposeTransient hypogammaglobulinemia of infancy (THI) is a common immunodeficiency, but definitive diagnosis can only be made retrospectively. While the pathogenesis is still unknown, abnormalities have been reported in the B cell compartment. In this study, we analysed the B cell subsets of patients with an initial THI diagnosis (n=20) and compared them with those of healthy age-matched Turkish children (n=72).