Blood viscosity changes in slow coronary flow patients

Ergun-Cagli K., Ileri-Gurel E., Ozeke O., Seringec N., Yalcinkaya A., Kocabeyoglu S., ...Daha Fazla

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, cilt.47, sa.1, ss.27-35, 2011 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 1
  • Basım Tarihi: 2011
  • Doi Numarası: 10.3233/ch-2010-1362
  • Dergi Adı: CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.27-35
  • Anahtar Kelimeler: Slow coronary flow, erythrocyte aggregation, plasma viscosity, erythrocyte deformability, CELL ANALYZER LORCA, ERYTHROCYTE AGGREGATION, ANGINA-PECTORIS, ARTERY FLOW, HEMORHEOLOGY, EXPRESSION, PARAMETERS, RESISTANCE, RHEOLOGY, THERAPY
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Microvascular dysfunction is implicated in the pathogenesis of slow coronary flow (SCF), but less attention has been paid to intrinsic properties of blood that can also impair the microcirculatory flow. In this study we aimed to evaluate the blood viscosity focusing on erythrocyte aggregation, erythrocyte deformability and plasma viscosity in SCF. Thirty-three patients with SCF (21 male, 54 +/- 12.8 years) and 23 subjects with normal coronary arteries (13 male, 59 +/- 10.3 years) were included in the study. Coronary flow was quantified by means of thrombolysis in myocardial infarction (TIMI) frame count and aggregation and deformability of erythrocytes were measured by an ektacytometer. Plasma viscosity was measured by a cone-plate viscometer. Aggregation amplitude (23 +/- 3.8 au vs. 15.7 +/- 6.1 au, respectively, p < 0.001) and area A index (area above syllectogram) (153.2 +/- 30.7 au.s vs. 124.9 +/- 49.3 au.s, respectively, p < 0.01) were higher in SCF patients. Aggregation half-time, aggregation index, elongation index and plasma viscosity values were similar between two groups. Correlation analysis revealed a significant relationship between the TIMI frame count for left anterior descending artery and aggregation amplitude in SCF patients (r = 0.679, p < 0.0001). The result of this study reveals changes in erythrocyte aggregation which may contribute to the pathophysiology of SCF. Larger studies are needed to make more robust conclusions on this issue.