CISPLATIN TOXICITY: IMPORTANCE OF OXIDATIVE STRESS AND EFFECT OF ANTIOXIDANTS

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Atıf İçin Kopyala

SABUNCUOĞLU S., ÖZGÜNEŞ H.

JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, cilt.74, sa.1, ss.18-25, 2011 (ESCI)

• Yayın Türü: Makale / Derleme
• Cilt numarası: 74 Sayı: 1
• Basım Tarihi: 2011
• Dergi Adı: JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
• Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
• Sayfa Sayıları: ss.18-25
• Hacettepe Üniversitesi Adresli: Evet

Özet

Cisplatin (CP) is one of the most widely used chemotherapeutic agents for the treatment of several human cancers; however, it has several side effects such as nephrotoxicity, hepatotoxicity, ototoxicity that limits the use of CP. Some studies have shown that CP increases free radical production and thereby oxidative damage. These findings indicate that oxidative stress plays an important role in CP toxicity. On the other hand, many studies have shown the preventive effect of antioxidant agents on CP toxicity. In this review, the importance of oxidative stress in CP toxicity and the preventive role of antioxidants has reviewed.