Stabilizing Role of Platelet P2Y(12) Receptors in Shear-Dependent Thrombus Formation on Ruptured Plaques

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Nergiz-Unal R., Cosemans J. M. E. M., Feijge M. A. H., van der Meijden P. E. J., Storey R. F., van Giezen J. J. J., ...More

PLOS ONE, vol.5, no.4, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 5 Issue: 4
  • Publication Date: 2010
  • Doi Number: 10.1371/journal.pone.0010130
  • Journal Name: PLOS ONE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Hacettepe University Affiliated: Yes

Abstract

Background: In most models of experimental thrombosis, healthy blood vessels are damaged. This results in the formation of a platelet thrombus that is stabilized by ADP signaling via P2Y(12) receptors. However, such models do not predict involvement of P2Y(12) in the clinically relevant situation of thrombosis upon rupture of atherosclerotic plaques. We investigated the role of P2Y(12) in thrombus formation on (collagen-containing) atherosclerotic plaques in vitro and in vivo, by using a novel mouse model of atherothrombosis.