Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus fumigatus


van der Linden J. W. M., Arendrup M. C., Warris A., Lagrou K., Pelloux H., Hauser P. M., ...More

EMERGING INFECTIOUS DISEASES, vol.21, no.6, pp.1041-1044, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 6
  • Publication Date: 2015
  • Doi Number: 10.3201/eid2106.140717
  • Journal Name: EMERGING INFECTIOUS DISEASES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1041-1044
  • Hacettepe University Affiliated: Yes

Abstract

To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles.