Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus fumigatus

van der Linden, J.; Arendrup, M.; Warris, A.; Lagrou, K.; Pelloux, H.; Hauser, P.; Chryssanthou, E.; Mellado, E.; Kidd, S.; Tortorano, A.; Dannaoui, E.; Gaustad, P.; Baddley, J.; Uekoetter, A.; Lass-Floerl, C.; Klimko, N.; Moore, C.; Denning, D.; Pasqualotto, A.; Kibbler, C.; Arikan-Akdagli, SEVTAP; Andes, D.; Meletiadis, J.; Naumiuk, L.; Nucci, M.; Melchers, W.; Verweij, P.

doi:10.3201/eid2106.140717

Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus fumigatus

van der Linden J. W. M., Arendrup M. C., Warris A., Lagrou K., Pelloux H., Hauser P. M., ...More

EMERGING INFECTIOUS DISEASES, vol.21, no.6, pp.1041-1044, 2015 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 21 Issue: 6
Publication Date: 2015
Doi Number: 10.3201/eid2106.140717
Journal Name: EMERGING INFECTIOUS DISEASES
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1041-1044
Hacettepe University Affiliated: Yes

Abstract

To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles.