Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus fumigatus

van der Linden, J.; Arendrup, M.; Warris, A.; Lagrou, K.; Pelloux, H.; Hauser, P.; Chryssanthou, E.; Mellado, E.; Kidd, S.; Tortorano, A.; Dannaoui, E.; Gaustad, P.; Baddley, J.; Uekoetter, A.; Lass-Floerl, C.; Klimko, N.; Moore, C.; Denning, D.; Pasqualotto, A.; Kibbler, C.; Arikan-Akdagli, SEVTAP; Andes, D.; Meletiadis, J.; Naumiuk, L.; Nucci, M.; Melchers, W.; Verweij, P.

doi:10.3201/eid2106.140717

Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus fumigatus

van der Linden J. W. M., Arendrup M. C., Warris A., Lagrou K., Pelloux H., Hauser P. M., ...Daha Fazla

EMERGING INFECTIOUS DISEASES, cilt.21, sa.6, ss.1041-1044, 2015 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 21 Sayı: 6
Basım Tarihi: 2015
Doi Numarası: 10.3201/eid2106.140717
Dergi Adı: EMERGING INFECTIOUS DISEASES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1041-1044
Hacettepe Üniversitesi Adresli: Evet

Özet

To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles.