Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus fumigatus

van der Linden, J.; Arendrup, M.; Warris, A.; Lagrou, K.; Pelloux, H.; Hauser, P.; Chryssanthou, E.; Mellado, E.; Kidd, S.; Tortorano, A.; Dannaoui, E.; Gaustad, P.; Baddley, J.; Uekoetter, A.; Lass-Floerl, C.; Klimko, N.; Moore, C.; Denning, D.; Pasqualotto, A.; Kibbler, C.; Arikan-Akdagli, SEVTAP; Andes, D.; Meletiadis, J.; Naumiuk, L.; Nucci, M.; Melchers, W.; Verweij, P.

doi:10.3201/eid2106.140717

Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus fumigatus

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van der Linden J. W. M., Arendrup M. C., Warris A., Lagrou K., Pelloux H., Hauser P. M., ...More

EMERGING INFECTIOUS DISEASES, vol.21, no.6, pp.1041-1044, 2015 (SCI-Expanded)

Publication Type: Article / Article
Volume: 21 Issue: 6
Publication Date: 2015
Doi Number: 10.3201/eid2106.140717
Journal Name: EMERGING INFECTIOUS DISEASES
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1041-1044
Hacettepe University Affiliated: Yes

Abstract

To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles.