NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, vol.208, pp.395-399, 2003 (SCI-Expanded)
Adsorption and desorption capacity of hydrogel depends on the IA content in the hydrogel. The hydrophilic groups of the hydrogels increase with an increase in IA content. Thus, the swelling ratio of hydrogels increases. This increase results with an increment or a decrement in the adsorption or desorption capacity of hydrogel. For the practical biomedical application of the hydrogel, it is therefore important to know that the influence of IA content on the biocompatibility of PVP/IA hydrogel. For this reason, poly(n-vinyl 2-pyrrolidone/itaconic acid) hydrogels have been synthesized by γ-rays in different compositions and their biocompatibility have been investigated as in vivo and some biochemical parameters (UN, ALT, ELISA) of mice serum and histology of their tissues have been examined. UN, ALT, ELISA and histopathological analyses result can be attributed to a normal defense mechanism of the tissue against foreign body. It shows that poly(n-vinyl 2-pyrrolidone/itaconic acid) hydrogels can be directly used as biomedical materials.