Antioxidant and antigenotoxic effects of lycopene in obstructive jaundice

Aydin S., Tokac M., Taner G., Arikok A. T., Dundar H. Z., Ozkardes A. B., ...More

JOURNAL OF SURGICAL RESEARCH, vol.182, no.2, pp.285-295, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 182 Issue: 2
  • Publication Date: 2013
  • Doi Number: 10.1016/j.jss.2012.10.031
  • Journal Name: JOURNAL OF SURGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.285-295
  • Keywords: Lycopene, Cholestasis, Obstructive jaundice, Alkaline single cell gel electrophoresis, DNA damage, Oxidative stress, Peripheral lymphocytes, Liver, Kidney, OXIDATIVE DNA-DAMAGE, BILE-DUCT LIGATION, OXYGEN-FREE RADICALS, LIPID-PEROXIDATION, EXTRAHEPATIC CHOLESTASIS, ISCHEMIA-REPERFUSION, RENAL SUSCEPTIBILITY, BILIARY OBSTRUCTION, HEPATIC-INJURY, BETA-CAROTENE
  • Hacettepe University Affiliated: Yes

Abstract

Background: Obstructive jaundice, a frequently observed condition caused by obstruction of the common bile duct or its flow and seen in many clinical situations, may end up with serious complications like sepsis, immune depression, coagulopathy, wound breakdown, gastrointestinal hemorrhage, and hepatic and renal failures. Intrahepatic accumulation of reactive oxygen species is thought to be an important cause for the possible mechanisms of the pathogenesis of cholestatic tissue injury from jaundice. Carotenoids have been well described that are able to scavenge reactive oxygen species. Lycopene, a carotenoid present in tomatoes, tomato products, and several fruits and vegetables, have been suggested to have antioxidant activity, so may play a role in certain diseases related to the oxidative stress. The aim of the present study was to determine the effects of lycopene on oxidative stress and DNA damage induced by experimental biliary obstruction in Wistar albino rats.