The Complementary Role of Ga-68-DOTATATE PET/CT in Neuroblastoma

TELLİ T., ERGÜN E., VOLKAN SALANCI B., Kiratli P. O.

CLINICAL NUCLEAR MEDICINE, vol.45, no.4, pp.326-329, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Editorial Material
  • Volume: 45 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.1097/rlu.0000000000002961
  • Journal Name: CLINICAL NUCLEAR MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.326-329
  • Hacettepe University Affiliated: Yes

Abstract

A girl diagnosed with neuroblastoma at 33 months underwent I-123-MIBG scan after surgery and chemoradiotherapy. Although MIBG scan showed complete response, the bone marrow biopsy showed refractory disease. Therefore, she underwent Ga-68-DOTATATE PET/CT, which revealed bone marrow involvement and Ga-68-DOTATATE-avid brain metastasis. Rare physiological pineal gland uptake was also depicted. Ga-68-DOTATATE PET/CT showed active progressive disease earlier, before it was detectable with MIBG scan. For patients with MIBG-negative relapsed/refractory disease, Ga-68-DOTATATE may have an important role in restaging, detecting unsuspected metastasis, therapy planning.