Adrenalin tolerance does not prevent bacterial translocation in a murine burn model

Baykal A., Iskit A., Kaynaroglu V., Guc M., Hascelik G. , Sayek I., ...Daha Fazla

INTERNATIONAL SURGERY, cilt.85, ss.18-22, 2000 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 85 Konu: 1
  • Basım Tarihi: 2000
  • Sayfa Sayıları: ss.18-22


Burn injury causes mesenteric vasoconstriction and bacterial translocation. Since catecholamines are powerful vasoconstrictors and elevated immediately after burn injury, we hypothesised that adrenaline tolerance might decrease burn-induced mesenteric vasoconstriction and bacterial translocation. Adrenaline tolerance was developed in Swiss albino mice. Adrenaline tolerant and control animals were subdivided into sham-burn and burn subgroups. 24 h after sham-burn or burn injury, specimens were obtained for microbiological evaluation. Also, in a separate group of adrenaline tolerant and control animals, superior mesenteric blood flow was measured. Burn injury increased bacterial translocation rate in both control (P = 0.001) and adrenaline tolerant groups (P = 0.0351). The caecal bacterial level increase was significant after burn injury in control groups (P = 0.0004) but was not significant in adrenaline tolerant animals (P = 0.743). Mesenteric blood flow was decreased significantly by burn injury in both control and adrenaline tolerant animals (P < 0.00001). The results showed that catecholamines do not mediate postburn mesenteric vasoconstriction or bacterial translocation.